Research in biophysics, with an emphasis on computational design and study of druglike agents that might be useful for treatments of various diseases.
Select Publications/Presentations
Design of Dual Allosteric Inhibitors of B-Raf and C-Raf Kinases for Cancer Treatment, International J. of Pharmaceutical & Biological Science Archive, 9(4), 12-26 (2021).
Computational Design of Druglike Allosteric Inhibitors of AXL and MET Receptor Tyrosine Kinases” with K Sureshkumar, Biophysical J. 116(3), 560a (2019).
Simultaneous Allosteric Inhibition of AXL and MET Receptor Tyrosine Kinases, with K Sureshkumar, International Journal of Biological & Pharmaceutical Research, 9(4):98-109 (2018).
Computer-Aided Design of Small Molecule Inhibitors of Receptor Tyrosine Kinases (RTKs), 4th International Congress on Drug Discovery, Design and Development, Chicago, IL (2017).
Computational Design of Druglike Allosteric Inhibitors of Protein Kinase B (PKB) and Serum and Glucocorticoid-regulated Kinase 1 (SGK1), with A. Parmar and K. Sheth, International Journal of Computational Bioinformatics and In Silico Modeling, 5(5): 858-870 (2016).
Supervised Research Projects with Undergraduates
Krishna Sureshkumar, Atom-by-Atom: Creating Allosteric Inhibitors of AXL and MET Kinases.
Amrit Parmar and Krishna Sheth, Small Molecule Inhibitors of PKB and SGK Kinases.
Amrit Parmar, Computational Design of Allosteric Inhibitors of the AKT Kinase.
Meehir Shah, Allosteric Inhibitors of PKC Zeta Kinases.
Kayla Spector, Computational Design of Small Molecules with Specific LYN Binding.
Raha Ghassem, Computational Design of Plk1-Specific Inhibiting Molecules,.
Sean Vanadia, Computational Design of Small Molecule Inhibitors of Plk1 Kinase.
Krupa Jani, Computational Design of Targeted Inhibitors of Polo-like Kinase 1 (Plk1).
Yanique Riviere, Investigation of the Electrical Activity of the Heart.
Krupa Jani, Design of druglike small molecules for possible anticancer applications.
Greg Prisco, Interactions of small molecule mimetics with Bcl-Xl and Bcl-2 proteins.
Kevin Chen, Predicting and improving potential anticancer proteomimetics with computational modeling.
Kevin Chen, Binding affinities of BH3 domain and Bcl-Xl protein.
Calvin Woo, Inhibition of Bfl-1 protein by pro-apoptotic protein mimetics.
Greg Prisco, Generating and Evaluating Putative EH1-like Motifs Using Computational Methods.
Timothy Craven, Investigation into the Use of Substituted Metalloporphyrin Complexes as Catalysts in Photoelectrolysis.
Jenn Miller, Superconducting Josephson Tunneling Study using a Mechanical Analogy.
Nita Silimkhan, Study of Mo(6-x)MxTe8 Semiconductors.
David Henningsen, Thermoelectric Properties of Doped Rhenium Tellurides.
Homar Barcena, Preparation of Doped Rhenium Tellurides.
Heather McAllister, Preparation of Rheniumsellenotellurides.
Steve Schwarz, Temperature Dependence of Seebeck Coefficient and Resistivity of Doped Rhenium Tellurides.
Brian Cahill, Transport Properties of Mixed Rhenium Chalcogenides.
Kim Chamberlain, Thermoelectric Properties of Narrow Gap Semiconductors.
Sean Hunter, Programming for Thermoelectric Measurements.
Chris Dritt, Four-probe Measurement Apparatus.
Greg Urbancik, Design of the Seebeck Coefficient Measurement Apparatus.